MesotheLioma Research ....

Britain is currently facing an epidemic of asbestos-related illness. Unfortunately there is very little research going on into mesothelioma in the UK. Bart’s Mesothelioma Research is aiming to raise the profile of this neglected group of diseases by offering our patients the best possible treatment and by conducting first-rate clinical and laboratory research.see that http://www.mesothelioma.co.uk/index.htm

At Bart’s we have one of the largest outpatient clinics in the UK for patients with mesothelioma.At Bart’s we have one of the largest outpatient clinics in the UK for patients with mesothelioma. Typically our doctors see two or three new patients weekly. We also see a large number of patients who have completed treatment and are being followed up. We take a very positive view of treatment for mesothelioma and our patients are treated as individualsWe take a very positive view of treatment for mesothelioma and our patients are treated as individuals with treatment tailored accordingly. Treatments that we use include chemotherapy, radiotherapy and surgery. All patients are assessed in detail for symptoms by our team which also includes cancer specialist nurses.

Mesothelioma is cancer of the lung pleura or the abdominal peritoneum. The cancer arises in the membranous coverings of the lungs or bowels. Eventually the membrane becomes thickened and rubbery. Problems with breathlessness, chest pain and cough occur in many patients, though modern treatments can be very effective at abolishing these symptoms. Other symptoms that we see include weight loss, low energy levels and night-time sweating. Surgery to remove the cancer can be done in a few patients but most patients are treated with chemotherapy, radiotherapy and supportive treatments such as painkillers and appetite-boosting tablets. No patient is identical to another and, as discussed above, all patients are treated as individuals.

Research is central to our approach. It is imperative that we learn more about mesothelioma so that we can help current patients as well as patients of the future. What we learn about mesothelioma will help us understand other types of cancer such as breast, bowel and conventional lung cancer. Research at Bart’s takes two forms:


Clinical Trials

We have a programme of clinical trials which was initiated in the mid 1990s. Treatments pioneered at Bart’s have become accepted around the world. We cannot afford to stop where we are however, and much more progress is needed. We always have clinical trials available for patients. We also offer the standard best available treatments for patients who prefer not to be included in research trials. Some patients prefer a ‘watch-and-wait’ approach and we are supportive of this. Mesothelioma cancers tend to vary in their speed of growth and a period of observation is often very appropriate. Click for details of ongoing clinical trials.

Laboratory Research

In our laboratory programme we are aiming to understand the biology of malignant mesothelioma. Click for further details of ongoing laboratory research.


That Message very thankful for Bart's Mesothelioma Research....We are all appreciate so much

Mesothelioma Stages

There are basically three stages of mesothelioma but we sure
about that if we handle 1st stage of mesothelioma so we handle
it and save the patient going to danger condition.so let see what
the stages ?


Staging is the process of finding out how far the cancer has spread. Staging of mesothelioma is based on imaging studies such as x-rays, CT scans, and MRI scans. The treatment and outlook for patients with mesothelioma largely depends on the stage (extent of spread) of their cancer. Since pleural mesothelioma occurs more commonly and has been studied the most, it is the only mesothelioma for which a staging classification exists.

The staging system most often used for mesothelioma is the Butchart system. This system is based mainly on the extent of the primary tumor mass, and divides mesotheliomas into stages I through IV.


Butchart Staging System

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* Stage I: Mesothelioma is present within the right or left pleura, and may also involve the lung, pericardium, or diaphragm (the muscle separating the chest from the abdomen) on the same side.






* Stage II: Mesothelioma invades the chest wall or involves the esophagus (food passage connecting the throat to the stomach), heart, or pleura on both sides. The lymph nodes in the chest may also be involved.


*



* Stage III: Mesothelioma has penetrated through the diaphragm into the peritoneum (lining of the abdominal cavity). Lymph nodes beyond those in the chest may also be involved.






Stage IV: There is evidence of distant metastases (spread through the bloodstream to other organs).

Another staging system has recently been developed by the American Joint Committee on Cancer (AJCC). This is a TNM system, similar to staging systems used for most other cancers. T stands for tumor (its size and how far it has spread to nearby organs), N stands for spread to lymph nodes and M is for metastasis (spread to distant organs).


TNM Staging System








 Stage I: Mesothelioma involves the right or left pleura. It may also have spread into the lung, pericardium, or diaphragm on the same side. It has not yet spread to the lymph nodes.




 Stage II: Mesothelioma has spread from the pleura on one side to the nearby peribronchial and/or hilar lymph nodes next to the lung on the same side. It may also have spread into the lung, pericardium, or diaphragm on the same side.






 Stage III: Mesothelioma has spread into the chest wall muscle, ribs, heart, esophagus, or other organs in the chest on the same side as the primary tumor, with or without spread to subcarinal and/or mediastinal lymph nodes on the same side as the main tumor. Subcarinal nodes are located at the point where the windpipe branches to the left and right lungs. Mediastinal lymph nodes are located in the space behind the chest bone in front of the heart. Mesotheliomas with the same extent of local spread as in stage II that have also spread to subcarinal and/or mediastinal lymph nodes on the same side are also included in stage III.








* Stage IV: Mesothelioma has spread into the lymph nodes in the chest on the side opposite that of the primary tumor, or directly extends to the pleura or lung on the opposite side, or directly extends into the peritoneum, or directly extends into organs in the abdominal cavity or neck. Any mesothelioma with evidence of distant metastases (spread to other organs through the bloodstream) or spread to organs beyond the chest or abdomen is included in this stage.



Although the recently developed TNM classification is the most detailed and precise, the original Butchart staging system is still used most often to describe the spread of pleural mesotheliomas. Understanding these staging systems for mesothelioma is important both for estimating prognosis, and also for assessing therapeutic options.
Prognostic Factors Younger age at diagnosis, good general state of health and absence of weight loss are associated with a more favorable prognosis.


Mesothelioma are usually of three different cell types (histological analysis): 1) epithelial cell type - has the most favorable prognosis; 2) sarcomatoid cell type - carries the worst prognosis and 3) mixed cell type - has an intermediate prognosis.


Patients should also educate themselves about mesothelioma and treatment options and reach out to available resources to make coping with a mesothelioma diagnosis easier


Well Conditions depend the values what her/him relation follow the patients and Patient also follow the conditons
what did he or she feel ? So life is so short but not easier at that conditions, but we follow the rule so life its so
Easier ...Please save humain beings..

Mesothelioma Treatment

If you are a victim of Mesothelioma cancer, how will you get into Mesothelioma treatment?

Mesothelioma treatments are broken down into two categories:


1.Traditional treatments

Traditional mesothelioma treatments are similar to other standard cancer treatment modalities.

Two or more traditional mesothelioma treatments are often used together to better combat cancerous cells.

Traditional mesothelioma treatments are often used in combination with one-another to best target cancer cells.

2  .New treatments.

New mesothelioma treatments are in the process of ongoing research, development and testing.

New mesothelioma treatments are being evaluated in mesothelioma clinical trials in hopes of a mesothelioma cure.

While mesothelioma treatments are slowly inhibiting the victim from being able to enjoy the life they have left, big business is slowly killing the rights of mesothelioma symptoms victims all over the country.

Most of the Mesothelioma treatment options are too high in price that ordinary victims cannot afford to have such treatment.

Various Mesothelioma Treatments

* Bronchoscopy


* Biopsy


* CT scans


* Laparocoscopy


* Mediastinoscopy


* Thorocoscopy


* Peritoneoscopy


* Radiotherapy


* X-ray


* Fluid drainage


* MRI scan

.
Life just like a Rose believe me just do proper treatment and take a medicines in a proper time and listen my
followers PLZ SAVE THE ALL CANCER PATEINTS through this proper treatment I request to You All ..

Symptoms of Mesothelioma

. This a general list of symptoms for different types of mesothelioma:


* early asbestos symptoms in humans are associated with breathing problems in general asbestosis mesothelioma symptoms are easily confused with those of other asbestos related diseases
* abdominal mesothelioma symptoms are pain in the abdominal region and loss of mobility in that area
* loss of breath and chest pain are acute asbestos symptoms
* exposure to asbestos does not cause immediate symptoms, but will develop some breathing issues over a longer period of time
* signs and symptoms of mesothelioma are confusing at first, but in time they become clear for doctors and the are able to determine exactly what kind of disease is infecting the body




Mesothelioma Symptoms and Diagnosis
Right after a general doctor decides that the symptoms a person is experiencing are a sign of mesothelioma, he will send the individual to a specialist in order to have specific tests performed before a preliminary diagnosis can be set. Asbestosis diagnosis follows the same procedures. The dangers of not recognizing asbestos diseases symptoms are high, and can result in serious health problems.

Mesothelioma presents with breathing issues as symptoms because the first organs to be affected by the disease are the lungs. That it is why mesothelioma cancer treatments also aim to reduce pain and breathing problems experienced by the patient.

Recognizing mesothelioma symptoms is crucial because as the cancer develops it becomes more difficult to treat. Most of the times mesothelioma cancer is discovered right before it reaches the second stage of development, at which point doctors consider that it is a little too late. Highest survival rates are registered by cases when mesothelioma is discovered a few months after starting to develop.

Mesothelioma Prognosis

The term prognosis is used to describe the likely outcome of a disease, how long a diagnosed patient is expected to live, and the quality of life expected during that time. This article discusses the prognosis for mesothelioma patients affected on a multitude of levels.



If a patient is diagnosed once the disease has reached the advanced stages, treatment options are limited and prognosis is often compromised. A patient's overall health status and age greatly affects the prognosis. Cancer that has not metastasized to other areas of the body gives physicians a lot more treatment options and improves a patient's prognosis dramatically.


Pleural mesothelioma patients have a poorer prognosis if they are experiencing chest pain, shortness of breath, inability to perform daily tasks, weight loss, a low red blood cell count, a high white blood cell count, and high blood levels of a substance called LDH (lactate dehydrogenase, an enzyme). Pleural mesothelioma patients who experience these symptoms usually receive a prognosis ranging between six and 12 months.


The median survival of patients diagnosed with malignant mesothelioma from time of first dignosis is one year; in male patients or those with elevated white-cell counts, thrombocytosis or anemia, the prognosis is far worse. The presence of certain biochemical markers, as well increased vascularity or the presence of the SV40 virus in the tumor, are other indicators that the prognosis would be more serious. The fibrosarcomatus type carries the worst prognosis, while the mixed (a combination of both kinds) comes in between them.
However, many have overcome such a poor prognosis and have prolonged their life in a multitude of ways.

Causes of Mesothelioma

Asbestos Mesothelioma. The most common cause of mesothelioma is Asbestos. Asbestos is naturally occurring fibrous material which is used for insulation purposes. Mesothelioma is an occupational hazard and affects those who work in the industry associated with asbestos. This disease occurs due to inhalation and/or ingestion of the asbestos fibers. Mesothelioma is therefore also referred to as asbestos mesothelioma, as the greatest risk factor of mesothelioma cancer is asbestos.



Though asbestos is the most common cause of mesothelioma, there are also other possible factors that can induce the said form of cancer or further aggravate the negative effect of asbestos. Chain smoking is one of them wherein nicotine and tar from the cigarette can strip the natural protective lining in the lungs inducing more pleural effusion immunosuppressive effects. There are also particular viruses that have been determined to be potential cause of mesothelioma. Some studies have linked the Simian virus to some mesothelioma cases yet there is still not definitive conclusion for this possibility.

Epithelioid Mesothelioma

Epithelioid mesothelioma is the most common cell type that is relatively uniform in shape and has a tubular pattern with a distinct cell nucleus. Epithelioid is the most common kind; 50-70% cases reported are of this type, which also has the best possibility of survival. This type affects the covering surrounding the internal organs and internal surfaces in the body.


Causes and symptoms of epithelioid mesothelioma:
There are various causes found of epithelioid mesothelioma. The most common cause of epithelioid mesothelioma is asbestos exposure where the fine particles and which are found thrown in the air either through sawing or cutting. Mainly the membrane lining of chest cavity, lungs, heart or abdominal cavity gets affected in epithelioid mesothelioma.

Symptoms of epithelioid mesothelioma:
Symptoms can occur after more than 40 to 50 years of being exposed to asbestos. Patients suffering from epithelioid mesothelioma can have a cough, weakness, tiredness along with inability to absorb nutrition causing weight loss. The breathlessness is caused when the tumor does not allow the lungs to expand and when it spreads further it results in severe chest pain.

Sarcomatoid Mesothelioma

Sarcomatoid mesothelioma is the least common of the four cellular types. It accounts for approximately 7 to 20 percent of cases. When viewed under a microscope,the malignant cells appear as elongated spindle-shaped cells that are irregularly shaped and often overlap one another.


Treatment and Prognosis

Each of the four cellular forms of mesothelioma is generally treated in the same way. Treatment is not based on the specific type of cells involved, but instead on the location of tumors and the stage of the cancer. Each type of cancer responds to treatment very differently. In general, patients with malignant sarcomatoid mesothelioma have a poorer prognosis than patients with the epithelioid type , as sarcomatoid cancers are more aggressive and more resistant to treatment. Unfortunately, the general prognosis for all the different types is usually poor, and the difference in prognosis between sarcomatoid, epithelioid, biphasic and desmoplastic cancers may amount to as little as a few months.

Biopsy and Histopathology

Patients undergoing medical evaluation to ascertain a diagnosis of mesothelioma will also have to undergo a variety of medical tests to determine the location and nature of the cancer.

mesothelioma chemotherapy

Mesothelioma chemotherapy uses chemical substance to cure this disease. Significant numbers of patients who have undergone other mesothelioma treatments such as radiotherapy and surgical treatment, but Mesothelioma chemotherapy results are not great enough, reason why continued research and development of newly mesothelioma chemotherapy are being done...


Mesothelioma chemotherapy is used if there is a risk of cancer recurrence, usually mesothelioma chemotherapy subsequent to surgical treatment. Another mesothelioma chemotherapy known treatment is the palliative chemotherapy which is used to cure the symptoms of the disease.

Mesothelioma Lung Cancer

Mesothelioma Lung Cancer is a form of cancer that develops in the tissues of cells that line the lungs, heart and stomach. Mesothelioma Lung Cancer tissues are called mesothelial cells and they become infected by inhaling particles of dust from asbestos fibers. Once these cells become infected they dry up the fluids surrounding these major organs of the body and tumors begin to develop. Mesothelioma Lung Cancer most common form is pleural mesothelioma which accounts for 75% of all malignant cases however Mesothelioma Lung Cancer are two other types peritoneal, and pericardial which you may be interested in reading about.




Mesothelioma Lung Cancer will require a lot of physical and emotional endurance, a strong family and social network, and expert medical and professional advice and assistance. Mesothelioma Lung Cancer best way to approach dealing with mesothelioma is to first learn everything that you can about the disease. Mesothelioma Lung Cancer should include the causes, symptoms, diagnosis, treatment, and prognosis of mesothelioma.




Cancer presents a very difficult challenge for doctors and the medical community in diagnosing the disease and in many cases patients with this disease are either not aware that they have it or do not ask the doctor to specifically check for symptoms.